Publications
Year
Paper
2017
M Caldera*, P Buphamalai*, F Müller, J Menche. Interactome-based approaches to human disease. Current Opinions in Systems Biology 3:88; 2017.
Abstract: https://doi.org/10.1016/j.coisb.2017.04.015
Abstract: https://doi.org/10.1016/j.coisb.2017.04.015
2017
Albrecht F, List M, Bock C, Lengauer T. DeepBlueR: large-scale epigenomic analysis in R. Bioinformatics. 2017 Jul 1;33(13):2063-2064. doi: 10.1093/bioinformatics/btx099.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28334349
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28334349
2017
Andergassen D, Dotter CP, Wenzel D, Sigl V, Bammer PC, Muckenhuber M, Mayer D, Kulinski TM, Theussl HC, Penninger JM, Bock C, Barlow DP, Pauler FM, Hudson QJ. Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression. Elife. 2017 Aug 14;6. pii: e25125. doi: 10.7554/eLife.25125.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28806168
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28806168
2017
Bartosova M, Schaefer B, Bermejo JL, Tarantino S, Lasitschka F, Macher-Goeppinger S, Sinn P, Warady BA, Zaloszyc A, Parapatics K, Májek P, Bennett KL, Oh J, Aufricht C, Schaefer F, Kratochwill K, Schmitt CP. Complement Activation in Peritoneal Dialysis-Induced Arteriolopathy. J Am Soc Nephrol. 2017 Oct 18. pii: ASN.2017040436. doi: 10.1681/ASN.2017040436. [Epub ahead of print].
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29046343
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29046343
2017
Bergthaler A, Menche J. The immune system as a social network. Nat Immunol. 2017 Apr 18;18(5):481-482. doi: 10.1038/ni.3727. No abstract available.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28418389
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28418389
2017
Boidol B, Kornauth C, van der Kouwe E, Prutsch N, Kazianka L, Gültekin S, Hoermann G, Mayerhoefer ME, Hopfinger G, Hauswirth A, Panny M, Aretin MB, Hilgarth B, Sperr WR, Valent P, Simonitsch-Klupp I, Moriggl R, Merkel O, Kenner L, Jäger U, Kubicek S, Staber PB. First in human response of BCL-2 inhibitor venetoclax in T-cell prolymphocytic leukemia. Blood. 2017 Sep 27. pii: blood-2017-05-785683. doi: 10.1182/blood-2017-05-785683. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28972014
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28972014
2017
Brockmann M, Blomen VA, Nieuwenhuis J, Stickel E, Raaben M, Bleijerveld OB, Altelaar AFM, Jae LT, Brummelkamp TR. Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling. Nature. 2017 Jun 8;546(7657):307-311. doi: 10.1038/nature22376. Epub 2017 May 31.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28562590
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28562590
2017
Busch CJ, Hendrikx T, Weismann D, Jäckel S, Walenbergh SM, Rendeiro AF, Weißer J, Puhm F, Hladik A, Göderle L, Papac-Milicevic N, Haas G, Millischer V, Subramaniam S, Knapp S, Bennett KL, Bock C, Reinhardt C, Shiri-Sverdlov R, Binder CJ. Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice. Hepatology. 2017 Apr;65(4):1181-1195. doi: 10.1002/hep.28970. Epub 2017 Feb 3.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27981604
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27981604
2017
Conte C, Roscini L, Sardella R, Mariucci G, Scorzoni S, Beccari T, Corte L. Toll Like Receptor 4 Affects the Cerebral Biochemical Changes Induced by MPTP Treatment. Neurochem Res. 2017 Feb;42(2):493-500. doi: 10.1007/s11064-016-2095-6. Epub 2017 Jan 21.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28108849
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28108849
2017
Datlinger P, Rendeiro AF, Schmidl C, Krausgruber T, Traxler P, Klughammer J, Schuster LC, Kuchler A, Alpar D, Bock C. Pooled CRISPR screening with single-cell transcriptome readout. Nat Methods. 2017 Mar;14(3):297-301. doi: 10.1038/nmeth.4177. Epub 2017 Jan 18.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28099430
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28099430
2017
Erman B, Bilic I, Hirschmugl T, Salzer E, Boztug H, Sanal Ö, Çağdaş Ayvaz D, Tezcan I, Boztug K. Investigation of Genetic Defects in Severe Combined Immunodeficiency Patients from Turkey by Targeted Sequencing. Scand J Immunol. 2017 Mar;85(3):227-234. doi: 10.1111/sji.12523.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28109013
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28109013
2017
Farrokhi S, Shabani M, Aryan Z, Zoghi S, Krolo A, Boztug K, Rezaei N. MHC class II deficiency: Report of a novel mutation and special review. Allergol Immunopathol (Madr). 2017 Jul 1. pii: S0301-0546(17)30077-0. doi: 10.1016/j.aller.2017.04.006. [Epub ahead of print] Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28676232
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28676232
2017
Fazel A, Kashef S, Aleyasin S, Harsini S, Karamizadeh Z, Zoghi S, Flores SK, Boztug K, Rezaei N. Novel AICDA mutation in a case of autosomal recessive hyper-IgM syndrome, growth hormone deficiency and autoimmunity. Allergol Immunopathol (Madr). 2017 Jan - Feb;45(1):82-86. doi: 10.1016/j.aller.2016.08.005. Epub 2016 Oct 24.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27789066
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27789066
2017
Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, Fürnrohr BG, Lechner S, Dunzendorfer-Matt T, Scheffzek K, Bennett KL, Superti-Furga G, Lindner HH, Stasyk T, Huber LA. LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning. J Cell Biol. 2017 Oct 9. pii: jcb.201703061. doi: 10.1083/jcb.201703061. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28993467
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28993467
2017
Fogg CN, Kovats DE, Berger B. 2017 ISCB Overton Prize: Christoph Bock. F1000Res. 2017 Jun 26;6. pii: ISCB Comm J-999. doi: 10.12688/f1000research.11586.1. eCollection 2017.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28713546
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28713546
2017
Forment JV, Herzog M, Coates J, Konopka T, Gapp BV, Nijman SM, Adams DJ, Keane TM, Jackson SP. Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells. Nat Chem Biol. 2017 Jan;13(1):12-14. doi: 10.1038/nchembio.2226. Epub 2016 Oct 31.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27820796
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27820796
2017
Göschl L, Preglej T, Hamminger P, Bonelli M, Andersen L, Boucheron N, Gülich AF, Müller L, Saferding V, Mufazalov IA, Hirahara K, Seiser C, Matthias P, Penz T, Schuster M, Bock C, Waisman A, Steiner G, Ellmeier W. A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. J Autoimmun. 2017 Sep 27. pii: S0896-8411(17)30595-4. doi: 10.1016/j.jaut.2017.09.008. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28964722
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28964722
2017
Hadzijusufovic E, Albrecht-Schgoer K, Huber K, Hoermann G, Grebien F, Eisenwort G, Schgoer W, Herndlhofer S, Kaun C, Theurl M, Sperr WR, Rix U, Sadovnik I, Jilma B, Schernthaner GH, Wojta J, Wolf D, Superti-Furga G, Kirchmair R, Valent P. Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site. Leukemia. 2017 Nov;31(11):2388-2397. doi: 10.1038/leu.2017.245. Epub 2017 Jul 31.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28757617
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28757617
2017
Hegazy AN, West NR, Stubbington MJT, Wendt E, Suijker KIM, Datsi A, This S, Danne C, Campion S, Duncan SH, Owens BMJ, Uhlig HH, McMichael A; Oxford IBD Cohort Investigators, Bergthaler A, Teichmann SA, Keshav S, Powrie F. Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation. Gastroenterology. 2017 Nov;153(5):1320-1337.e16. doi: 10.1053/j.gastro.2017.07.047. Epub 2017 Aug 4.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28782508
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28782508
2017
Houben T, Oligschlaeger Y, Bitorina AV, Hendrikx T, Walenbergh SMA, Lenders MH, Gijbels MJJ, Verheyen F, Lütjohann D, Hofker MH, Binder CJ, Shiri-Sverdlov R. Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation. Sci Rep. 2017 Oct 2;7(1):12550. doi: 10.1038/s41598-017-13058-z.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28970532
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28970532
2017
Houben T, Oligschlaeger Y, Hendrikx T, Bitorina AV, Walenbergh SMA, van Gorp PJ, Gijbels MJJ, Friedrichs S, Plat J, Schaap FG, Lütjohann D, Hofker MH, Shiri-Sverdlov R. Cathepsin D regulates lipid metabolism in murine steatohepatitis. Sci Rep. 2017 Jun 14;7(1):3494. doi: 10.1038/s41598-017-03796-5.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28615690
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28615690
2017
J Menche*, E Guney*, A. Sharma, P.J. Branigan, M.J. Loza, F. Baribaud, R. Dobrin, A.-L. Barabási. Integrating personalized gene expression profiles into predictive disease-associated gene pool. npj Systems Biology & Applications 3:10; 2017. doi:10.1038/s41540-017-0009-0
Abstract: http://www.nature.com/articles/s41540-017-0009-0
Abstract: http://www.nature.com/articles/s41540-017-0009-0
2017
J Menche*, E Guney*, A. Sharma, P.J. Branigan, M.J. Loza, F. Baribaud, R. Dobrin, A.-L. Barabási. Integrating personalized gene expression profiles into predictive disease-associated gene pool. npj Systems Biology & Applications 3:10; 2017. doi:10.1038/s41540-017-0009-0.
Abstract: http://www.nature.com/articles/s41540-017-0009-0
Abstract: http://www.nature.com/articles/s41540-017-0009-0
2017
Jäckel S, Kiouptsi K, Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C, Subramaniam S, Wilms E, Ebner K, Brühl MV, Rausch P, Baines JF, Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U, Ruf W, Reinhardt C. Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. Blood. 2017 Jul 27;130(4):542-553. doi: 10.1182/blood-2016-11-754416. Epub 2017 Jun 1.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28572286
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28572286
2017
Kager L, Bruce LJ, Zeitlhofer P, Flatt JF, Maia TM, Ribeiro ML, Fahrner B, Fritsch G, Boztug K, Haas OA. Band 3 nullVIENNA , a novel homozygous SLC4A1 p.Ser477X variant causing severe hemolytic anemia, dyserythropoiesis and complete distal renal tubular acidosis. Pediatr Blood Cancer. 2017 Mar;64(3). doi: 10.1002/pbc.26227. Epub 2016 Oct 8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27718309
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27718309
2017
Khamina K , Lercher A , Caldera M, Schliehe C , Vilagos B , Sahin M, Kosack L, Bhattacharya A, Májek P, Stukalov A, Sacco R, James LC, Pinschewer DD, Bennett KL, Menche J, Bergthaler A. Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein. PLoS Pathogens 13(12): e1006758; 2017.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29261807
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29261807
2017
Klughammer J, Dittrich M, Blom J, Mitesser V, Vogel U, Frosch M, Goesmann A, Müller T, Schoen C. Comparative Genome Sequencing Reveals Within-Host Genetic Changes in Neisseria meningitidis during Invasive Disease. PLoS One. 2017 Jan 12;12(1):e0169892. doi: 10.1371/journal.pone.0169892. eCollection 2017.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28081260
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28081260
2017
Korcsmaros T, Schneider MV, Superti-Furga G. Next generation of network medicine: interdisciplinary signaling approaches. Integr Biol (Camb). 2017 Feb 20;9(2):97-108. doi: 10.1039/c6ib00215c. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28106223
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28106223
2017
Kosack L, Gawish R, Lercher A, Vilagos B, Hladik A, Lakovits K, Bhattacharya A, Schliehe C, Mesteri I, Knapp S, Bergthaler A. The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis. Sci Rep. 2017 Sep 12;7(1):11289. doi: 10.1038/s41598-017-10637-y.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28900132
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28900132
2017
Kostel Bal S, Haskologlu S, Serwas NK, Islamoglu C, Aytekin C, Kendirli T, Kuloglu Z, Yavuz G, Dalgic B, Siklar Z, Kansu A, Ensari A, Boztug K, Dogu F, Ikinciogullari A. Multiple Presentations of LRBA Deficiency: a Single-Center Experience. J Clin Immunol. 2017 Nov;37(8):790-800. doi: 10.1007/s10875-017-0446-y. Epub 2017 Sep 27.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28956255
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28956255
2017
Kostrhon S, Kontaxis G, Kaufmann T, Schirghuber E, Kubicek S, Konrat R, Slade D. A histone-mimicking interdomain linker in a multidomain protein modulates multivalent histone binding. J Biol Chem. 2017 Oct 27;292(43):17643-17657. doi: 10.1074/jbc.M117.801464. Epub 2017 Sep 1.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28864776
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28864776
2017
Kral-Pointner JB, Schrottmaier WC, Horvath V, Datler H, Hell L, Ay C, Niederreiter B, Jilma B, Schmid JA, Assinger A, Mackman N, Knapp S, Schabbauer G. Myeloid but not epithelial tissue factor exerts protective anti-inflammatory effects in acid aspiration-induced acute lung injury. J Thromb Haemost. 2017 Aug;15(8):1625-1639. doi: 10.1111/jth.13737. Epub 2017 Jun 20.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28509332
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28509332
2017
Kubesova B, Pavlova S, Malcikova J, Kabathova J, Radova L, Tom N, Tichy B, Plevova K, Kantorova B, Fiedorova K, Slavikova M, Bystry V, Kissova J, Gisslinger B, Gisslinger H, Penka M, Mayer J, Kralovics R, Pospisilova S, Doubek M. Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status. Leukemia. 2017 Jul 24. doi: 10.1038/leu.2017.230. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28744014
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28744014
2017
Leite FGG, Bergthaler A, Skern T. Vaccinia virus G1 protein: absence of autocatalytic self-processing. Arch Virol. 2017 May 18. doi: 10.1007/s00705-017-3409-y. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28523522
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28523522
2017
Licciardello MP, Ringler A, Markt P, Klepsch F, Lardeau CH, Sdelci S, Schirghuber E, Müller AC, Caldera M, Wagner A, Herzog R, Penz T, Schuster M, Boidol B, Dürnberger G, Folkvaljon Y, Stattin P, Ivanov V, Colinge J, Bock C, Kratochwill K, Menche J, Bennett KL, Kubicek S. A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor. Nat Chem Biol. 2017 Jul;13(7):771-778. doi: 10.1038/nchembio.2382. Epub 2017 May 22.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28530711
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28530711
2017
Loregger A, Raaben M, Tan J, Scheij S, Moeton M, van den Berg M, Gelberg-Etel H, Stickel E, Roitelman J, Brummelkamp T, Zelcer N. Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2064-2074. doi: 10.1161/ATVBAHA.117.310002. Epub 2017 Sep 7.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28882874
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28882874
2017
Malenczyk K, Girach F, Szodorai E, Storm P, Segerstolpe Å, Tortoriello G, Schnell R, Mulder J, Romanov RA, Borók E, Piscitelli F, Di Marzo V, Szabó G, Sandberg R, Kubicek S, Lubec G, Hökfelt T, Wagner L, Groop L, Harkany T. A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover. EMBO J. 2017 Jul 14;36(14):2107-2125. doi: 10.15252/embj.201695347. Epub 2017 Jun 21.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28637794
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28637794
2017
Martins R, Knapp S. Heme and hemolysis in innate immunity: adding insult to injury. Curr Opin Immunol. 2017 Oct 26;50:14-20. doi: 10.1016/j.coi.2017.10.005. [Epub ahead of print] Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29107115
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29107115
2017
Matt U, Selchow P, Dal Molin M, Strommer S, Sharif O, Schilcher K, Andreoni F, Stenzinger A, Zinkernagel AS, Zeitlinger M, Sander P, Nemeth J. Chloroquine enhances the antimycobacterial activity of isoniazid and pyrazinamide by reversing inflammation-induced macrophage efflux. Int J Antimicrob Agents. 2017 Jul;50(1):55-62. doi: 10.1016/j.ijantimicag.2017.02.022. Epub 2017 May 12.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28506804
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28506804
2017
Maurer B, Farlik M, Sexl V. It is a differentiation game: STAT5 in a new role. Cell Death Differ. 2017 Jun;24(6):953-954. doi: 10.1038/cdd.2017.71. Epub 2017 May 12. No abstract available.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28498368
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28498368
2017
Mazouzi A, Battistini F, Moser SC, Ferreira da Silva J, Wiedner M, Owusu M, Lardeau CH, Ringler A, Weil B, Neesen J, Orozco M, Kubicek S, Loizou JI. Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH. Mol Cell. 2017 Nov 16;68(4):797-807.e7. doi: 10.1016/j.molcel.2017.10.021
Abstract: http://www.cell.com/molecular-cell/comments/S1097-2765(17)30796-7
Abstract: http://www.cell.com/molecular-cell/comments/S1097-2765(17)30796-7
2017
Meeuwsen JAL, van Duijvenvoorde A, Gohar A, Kozma MO, van de Weg SM, Gijsberts CM, Haitjema S, Björkbacka H, Fredrikson GN, de Borst GJ, den Ruijter HM, Pasterkamp G, Binder CJ, Hoefer IE, de Jager SCA. High Levels of (Un)Switched Memory B Cells Are Associated With Better Outcome in Patients With Advanced Atherosclerotic Disease. J Am Heart Assoc. 2017 Sep 7;6(9). pii: e005747. doi: 10.1161/JAHA.117.005747.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28882820
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28882820
2017
Menche J. Network medicine: a new paradigm for cardiovascular disease research and beyond. Cardiovasc Res. 2017 Aug 1;113(10):e29-e30. doi: 10.1093/cvr/cvx129. No abstract available.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28899006
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28899006
2017
Mezzadra R, Sun C, Jae LT, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, Broeks A, Horlings HM, Wessels LFA, Blank CU, Xiao Y, Heck AJR, Borst J, Brummelkamp TR, Schumacher TNM. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature. 2017 Sep 7;549(7670):106-110. doi: 10.1038/nature23669. Epub 2017 Aug 16.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28813410
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28813410
2017
Miller A, Nagy C, Knapp B, Laengle J, Ponweiser E, Groeger M, Starkl P, Bergmann M, Wagner O, Haschemi A. Exploring Metabolic Configurations of Single Cells within Complex Tissue Microenvironments. Cell Metab. 2017 Nov 7;26(5):788-800.e6. doi: 10.1016/j.cmet.2017.08.014. Epub 2017 Sep 7.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28889950
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28889950
2017
Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, Robinson-Garcia L, Schischlik F, Slavkovsky R, Kralovics R, Schuster M, Bock C, Ideker T, Jackson SP, Menche J, Loizou JI. Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia. Nat Commun. 2017 Nov 1;8(1):1238. doi: 10.1038/s41467-017-01439-x.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29089570
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29089570
2017
Müller H, Jimenez-Heredia R, Krolo A, Hirschmugl T, Dmytrus J, Boztug K, Bock C. VCF.Filter: interactive prioritization of disease-linked genetic variants from sequencing data. Nucleic Acids Res. 2017 May 17. doi: 10.1093/nar/gkx425. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28520890
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28520890
2017
Newland SA, Mohanta S, Clément M, Taleb S, Walker JA, Nus M, Sage AP, Yin C, Hu D, Kitt LL, Finigan AJ, Rodewald HR, Binder CJ, McKenzie ANJ, Habenicht AJ, Mallat Z. Type-2 innate lymphoid cells control the development of atherosclerosis in mice. Nat Commun. 2017 Jun 7;8:15781. doi: 10.1038/ncomms15781.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28589929
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28589929
2017
Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z. Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet. Nat Med. 2017 May;23(5):601-610. doi: 10.1038/nm.4315. Epub 2017 Apr 17.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28414328
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28414328
2017
Ozen A, Comrie WA, Ardy RC, Domínguez Conde C, Dalgic B, Beser ÖF, Morawski AR, Karakoc-Aydiner E, Tutar E, Baris S, Ozcay F, Serwas NK, Zhang Y, Matthews HF, Pittaluga S, Folio LR, Unlusoy Aksu A, McElwee JJ, Krolo A, Kiykim A, Baris Z, Gulsan M, Ogulur I, Snapper SB, Houwen RHJ, Leavis HL, Ertem D, Kain R, Sari S, Erkan T, Su HC, Boztug K, Lenardo MJ. CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis. N Engl J Med. 2017 Jul 6;377(1):52-61. doi: 10.1056/NEJMoa1615887. Epub 2017 Jun 28.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28657829
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28657829
2017
Perego M, Maurer M, Wang JX, Shaffer S, Müller AC, Parapatics K, Li L, Hristova D, Shin S, Keeney F, Liu S, Xu X, Raj A, Jensen JK, Bennett KL, Wagner SN, Somasundaram R, Herlyn M. A slow-cycling subpopulation of melanoma cells with highly invasive properties. Oncogene. 2017 Sep 18. doi: 10.1038/onc.2017.341. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28925403
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28925403
2017
Pfajfer L, Seidel MG, Houmadi R, Rey-Barroso J, Hirschmugl T, Salzer E, Antón IM, Urban C, Schwinger W, Boztug K, Dupré L. WIP deficiency severely affects human lymphocyte architecture during migration and synapse assembly. Blood. 2017 Oct 26;130(17):1949-1953. doi: 10.1182/blood-2017-04-777383. Epub 2017 Sep 13. No abstract available.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28903942
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28903942
2017
Pietarinen PO, Eide CA, Ayuda-Durán P, Potdar S, Kuusanmäki H, Andersson EI, Mpindi JP, Pemovska T, Kontro M, Heckman CA, Kallioniemi O, Wennerberg K, Hjorth-Hansen H, Druker BJ, Enserink JM, Tyner JW, Mustjoki S, Porkka K. Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors. Oncotarget. 2017 Apr 4;8(14):22606-22615. doi: 10.18632/oncotarget.15146.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28186983
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28186983
2017
Ponnuswamy P, Joffre J, Herbin O, Esposito B, Laurans L, Binder CJ, Tedder TF, Zeboudj L, Loyer X, Giraud A, Zhang Y, Tedgui A, Mallat Z, Ait-Oufella H. Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells. Sci Rep. 2017 Jun 23;7(1):4111. doi: 10.1038/s41598-017-04438-6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28646220
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28646220
2017
Puhm F, Binder CJ. Characterization of Natural IgM Antibodies Recognizing Oxidation-Specific Epitopes on Circulating Microvesicles. Methods Mol Biol. 2017;1643:147-154. doi: 10.1007/978-1-4939-7180-0_11.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28667535
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28667535
2017
Raaben M, Jae LT, Herbert AS, Kuehne AI, Stubbs SH, Chou YY, Blomen VA, Kirchhausen T, Dye JM, Brummelkamp TR, Whelan SP. NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.Cell Host Microbe. 2017 Nov 8;22(5):688-696.e5. doi: 10.1016/j.chom.2017.10.002.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29120745
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29120745
2017
Radic-Sarikas B, Halasz M, Huber KVM, Winter GE, Tsafou KP, Papamarkou T, Brunak S, Kolch W, Superti-Furga G. Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter. Sci Rep. 2017 Jun 8;7(1):3091. doi: 10.1038/s41598-017-03129-6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28596528
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28596528
2017
Radic-Sarikas B, Tsafou KP, Emdal KB, Papamarkou T, Huber KV, Mutz C, Toretsky JA, Bennett KL, Olsen JV, Brunak S, Kovar H, Superti-Furga G. Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities. Mol Cancer Ther. 2017 Jan;16(1):88-101. doi: 10.1158/1535-7163.MCT-16-0235. Epub 2016 Nov 15.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28062706
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28062706
2017
Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow AK, Martens H, Schwindling C, Calvigioni D, Bains JS, Máté Z, Szabó G, Yanagawa Y, Zhang MD, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath TL, Harkany T. Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes. Nat Neurosci. 2017 Feb;20(2):176-188. doi: 10.1038/nn.4462. Epub 2016 Dec 19.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27991900
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27991900
2017
Sage AP, Nus M, Bagchi Chakraborty J, Tsiantoulas D, Newland SA, Finigan AJ, Masters L, Binder CJ, Mallat Z. X-Box Binding Protein-1 Dependent Plasma Cell Responses Limit the Development of Atherosclerosis. Circ Res. 2017 Jul 21;121(3):270-281. doi: 10.1161/CIRCRESAHA.117.310884. Epub 2017 Jun 15.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28620068
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28620068
2017
Saluzzo S, Gorki AD, Rana BMJ, Martins R, Scanlon S, Starkl P, Lakovits K, Hladik A, Korosec A, Sharif O, Warszawska JM, Jolin H, Mesteri I, McKenzie ANJ, Knapp S. First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment. Cell Rep. 2017 Feb 21;18(8):1893-1905. doi: 10.1016/j.celrep.2017.01.071.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28228256
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28228256
2017
Saudemont B, Popa A, Parmley JL, Rocher V, Blugeon C, Necsulea A, Meyer E, Duret L. The fitness cost of mis-splicing is the main determinant of alternative splicing patterns. Genome Biol. 2017 Oct 30;18(1):208. doi: 10.1186/s13059-017-1344-6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29084568
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29084568
2017
Schischlik F, Kralovics R. Mutations in myeloproliferative neoplasms - their significance and clinical use. Expert Rev Hematol. 2017 Nov;10(11):961-973. doi: 10.1080/17474086.2017.1380515. Epub 2017 Sep 25.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28914569
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28914569
2017
Sedlyarova N, Rescheneder P, Magán A, Popitsch N, Rziha N, Bilusic I, Epshtein V, Zimmermann B, Lybecker M, Sedlyarov V, Schroeder R, Nudler E. Natural RNA Polymerase Aptamers Regulate Transcription in E. coli. Mol Cell. 2017 Jul 6;67(1):30-43.e6. doi: 10.1016/j.molcel.2017.05.025. Epub 2017 Jun 22.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28648779
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28648779
2017
Sheffield NC, Pierron G, Klughammer J, Datlinger P, Schönegger A, Schuster M, Hadler J, Surdez D, Guillemot D, Lapouble E, Freneaux P, Champigneulle J, Bouvier R, Walder D, Ambros IM, Hutter C, Sorz E, Amaral AT, de Álava E, Schallmoser K, Strunk D, Rinner B, Liegl-Atzwanger B, Huppertz B, Leithner A, de Pinieux G, Terrier P, Laurence V, Michon J, Ladenstein R, Holter W, Windhager R, Dirksen U, Ambros PF, Delattre O, Kovar H, Bock C, Tomazou EM. DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma. Nat Med. 2017 Mar;23(3):386-395. doi: 10.1038/nm.4273. Epub 2017 Jan 30.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28134926
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28134926
2017
Somasundaram R, Zhang G, Fukunaga-Kalabis M, Perego M, Krepler C, Xu X, Wagner C, Hristova D, Zhang J, Tian T, Wei Z, Liu Q, Garg K, Griss J, Hards R, Maurer M, Hafner C, Mayerhöfer M, Karanikas G, Jalili A, Bauer-Pohl V, Weihsengruber F, Rappersberger K, Koller J, Lang R, Hudgens C, Chen G, Tetzlaff M, Wu L, Frederick DT, Scolyer RA, Long GV, Damle M, Ellingsworth C, Grinman L, Choi H, Gavin BJ, Dunagin M, Raj A, Scholler N, Gross L, Beqiri M, Bennett K, Watson I, Schaider H, Davies MA, Wargo J, Czerniecki BJ, Schuchter L, Herlyn D, Flaherty K, Herlyn M, Wagner SN. Tumor-associated B-cells induce tumor heterogeneity and therapy resistance. Nat Commun. 2017 Sep 19;8(1):607. doi: 10.1038/s41467-017-00452-4.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28928360
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28928360
2017
Speckmann C, Sahoo SS, Rizzi M, Hirabayashi S, Karow A, Serwas NK, Hoemberg M, Damatova N, Schindler D, Vannier JB, Boulton SJ, Pannicke U, Göhring G, Thomay K, Verdu-Amoros JJ, Hauch H, Woessmann W, Escherich G, Laack E, Rindle L, Seidl M, Rensing-Ehl A, Lausch E, Jandrasits C, Strahm B, Schwarz K, Ehl SR, Niemeyer C, Boztug K, Wlodarski MW. Clinical and Molecular Heterogeneity of RTEL1 Deficiency. Front Immunol. 2017 May 1;8:449. doi: 10.3389/fimmu.2017.00449. eCollection 2017. Erratum in: Front Immunol. 2017 Oct 02;8:1250.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28507545
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28507545
2017
Speckmann C, Sahoo SS, Rizzi M, Hirabayashi S, Karow A, Serwas NK, Hoemberg M, Damatova N, Schindler D, Vannier JB, Boulton SJ, Pannicke U, Göhring G, Thomay K, Verdu-Amoros JJ, Hauch H, Woessmann W, Escherich G, Laack E, Rindle L, Seidl M, Rensing-Ehl A, Lausch E, Jandrasits C, Strahm B, Schwarz K, Ehl SR, Niemeyer C, Boztug K, Wlodarski MW. Corrigendum: Clinical and Molecular Heterogeneity of RTEL1 Deficiency. Front Immunol. 2017 Oct 2;8:1250. doi: 10.3389/fimmu.2017.01250. eCollection 2017.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28989339
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28989339
2017
Staring J, von Castelmur E, Blomen VA, van den Hengel LG, Brockmann M, Baggen J, Thibaut HJ, Nieuwenhuis J, Janssen H, van Kuppeveld FJ, Perrakis A, Carette JE, Brummelkamp TR. PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature. 2017 Jan 19;541(7637):412-416. doi: 10.1038/nature21032. Epub 2017 Jan 11.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28077878
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28077878
2017
Tsiantoulas D, Bot I, Ozsvar-Kozma M, Göderle L, Perkmann T, Hartvigsen K, Conrad DH, Kuiper J, Mallat Z, Binder CJ. Increased Plasma IgE Accelerate Atherosclerosis in Secreted IgM Deficiency. Circ Res. 2017 Jan 6;120(1):78-84. doi: 10.1161/CIRCRESAHA.116.309606. Epub 2016 Nov 30.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27903567
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27903567
2017
Tsiantoulas D, Kiss M, Bartolini-Gritti B, Bergthaler A, Mallat Z, Jumaa H, Binder CJ. Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development. Sci Rep. 2017 Jun 14;7(1):3540. doi: 10.1038/s41598-017-03688-8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28615655
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28615655
2017
Uras IZ, Scheicher RM, Kollmann K, Glösmann M, Prchal-Murphy M, Tigan AS, Fux DA, Altamura S, Neves J, Muckenthaler MU, Bennett KL, Kubicek S, Hinds PW, von Lindern M, Sexl V. Cdk6 contributes to cytoskeletal stability in erythroid cells. Haematologica. 2017 Jun;102(6):995-1005. doi: 10.3324/haematol.2016.159947. Epub 2017 Mar 2.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28255017
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28255017
2017
Valent P, Herndlhofer S, Schneeweiß M, Boidol B, Ringler A, Kubicek S, Gleixner KV, Hoermann G, Hadzijusufovic E, Müllauer L, Sperr WR, Superti-Furga G, Mannhalter C. TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML. Oncotarget. 2017 Apr 4;8(14):23061-23072. doi: 10.18632/oncotarget.15481.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28416739
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28416739
2017
Vesely C, Frech C, Eckert C, Cario G, Mecklenbräuker A, Zur Stadt U, Nebral K, Kraler F, Fischer S, Attarbaschi A, Schuster M, Bock C, Cavé H, von Stackelberg A, Schrappe M, Horstmann MA, Mann G, Haas OA, Panzer-Grümayer R. Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia. Leukemia. 2017 Jul;31(7):1491-1501. doi: 10.1038/leu.2016.365. Epub 2016 Nov 30.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27899802
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27899802
2017
Vladimer GI, Snijder B, Krall N, Bigenzahn JW, Huber KVM, Lardeau CH, Sanjiv K, Ringler A, Berglund UW, Sabler M, de la Fuente OL, Knöbl P, Kubicek S, Helleday T, Jäger U, Superti-Furga G. Global survey of the immunomodulatory potential of common drugs. Nat Chem Biol. 2017 Jun;13(6):681-690. doi: 10.1038/nchembio.2360. Epub 2017 Apr 24.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28437395
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28437395
2017
Weißer J, Ctortecka C, Busch CJ, Austin SR, Nowikovsky K, Uchida K, Binder CJ, Bennett KL. A Comprehensive Analytical Strategy To Identify Malondialdehyde-Modified Proteins and Peptides. Anal Chem. 2017 Apr 4;89(7):3847-3852. doi: 10.1021/acs.analchem.6b05065. Epub 2017 Mar 15.h
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28248083
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28248083
2017
Winter GE, Mayer A, Buckley DL, Erb MA, Roderick JE, Vittori S, Reyes JM, di Iulio J, Souza A, Ott CJ, Roberts JM, Zeid R, Scott TG, Paulk J, Lachance K, Olson CM, Dastjerdi S, Bauer S, Lin CY, Gray NS, Kelliher MA, Churchman LS, Bradner JE. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment. Mol Cell. 2017 Jul 6;67(1):5-18.e19. doi: 10.1016/j.molcel.2017.06.004. Epub 2017 Jun 29.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28673542
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28673542
2017
Winter GE. Protein degradation: DCAFinating splicing. Nat Chem Biol. 2017 Jun;13(6):575-576. doi: 10.1038/nchembio.2378. Epub 2017 Apr 24. No abstract available.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28437393
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28437393